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The study included 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination. The participants consumed either L. reuteri DSM 17938 + 10 microgram vitamin D3, or a placebo product that contained only vitamin D3 for 6 months. During the intervention period 12 subjects were infected, and 17 were fully vaccinated and sampled 28 days or more postvaccination.
The purpose of the study was to investigate the effect of L. reuteri DSM 17938 supplementation on SARS-CoV-2 specific antibody responses after natural infection or vaccination. Even though the primary outcome, based on infected subjects, failed to reach a statistically significant difference between the intervention groups, vaccinated individuals who consumed L. reuteri DSM 17938 showed significantly increased IgA antibody levels when 28 days or more had elapsed from vaccination.
The study was conducted at the Nutrition-Gut-Brain Interactions Research Centre, Örebro University, Sweden.
“To our knowledge, this is the first study to investigate the effect of probiotic supplementation on different SARS-CoV-2 antibody classes, including virus neutralizing antibodies in a antibody-naïve cohort”, says Prof. Robert Brummer, one of the researchers behind the study.
